Firefighters were called to a home off Wright Boulevard and 5th Avenue around 8:30 Sunday morning.
When they arrived, the entire home was engulfed in flames, according to Battalion Chief Jeremy Carter, with Conway Fire Department.
The intersection of Highway 501 and Wright Boulevard in Conway was shut down for several hours while crews cleaned up but it has now been reopened.
Carter says they think the home was abandoned. It was a total loss.
Horry County Fire Rescue assisted in fighting the fire.
The cause is under investigation.