Myrtle Beach police charged Urban Oshea, 43, with Manufacture, Distribute, Purchase or Possess Narcotic Drugs.
They charged Cecil Travis Francis, 43, with Manufacture, Distribution, Etc. Of Methamphetamine.
Police say the two were making methamphetamine in a room at the Polynesian Resort at 10th Ave. South and Ocean Boulevard.
Police found the lab about 2 a.m. Tuesday.
Some adjacent rooms were evacuated until officers removed the materials and made sure the room was safe.