At 12:28 p.m. on Wednesday, the West Florence Fire Department responded to a wreck with injuries on Otis Way at Enterprise Drive.
One car was on fire when firefighters arrived. One engine and one rescue truck responded with seven firefighters.
West Florence firefighters controlled the fire and started medical treatment on the injured until Florence County EMS arrived on scene.
All three patients were taken to an area hospital and the South Carolina Highway Patrol is investigating the cause of the wreck.