Fire broke out in a mobile home on Highway 707 in between Bay Road and Holmestown Road around 11:30 a.m. Wednesday.
It is a vacant mobile home, according to Horry County Fire Rescue Assistant Chief Justin Gibbins.
Investigators will be working to determine the cause of the fire.
One lane on Highway 707 was shut down, but it opened back up around 12:50 p.m.
Crews from Horry County, Surfside Beach, and Mur r ells Inlet-Garden City are on scene.