Horry County Fire Rescue responded to a house fire on Hagan Drive near Loris around noon Wednesday.
When firefighters arrived, they found a double-wide mobile home full of flames, according to spokesperson Leslie Yancey.
A neighbor saw the fire and called 911, according to Battalion Chief Brian VanAernem with Horry County Fire Rescue.
Mutual aid was called in from Loris, Tabor City and Fair Bluff.
The home is a total loss.
The family was not home at the time of the fire and the Red Cross is on the way to offer their assistance.
The fire is under investigation.