Officials say Leroy Davis,57, was killed in a house fire Sunday morning on Angel Loop, just outside of Mullins.
Marion County Coroner Jerry Richardson says it appears Davis died of natural causes. He says he had major health problems and could have had a heart attack.
Richardson says he won't know an exact cause of death until toxicology results are complete.
He says there is no evidence to indicate any criminal involvement in Davis' death.
Firefighters say the mobile home was covered in flames when they arrived on scene. They say Davis was trapped inside and died in the fire.
Davis' wife last saw him when she left for church this morning at 10, according to Richardson.
Fire investigators with South Carolina State Law Enforcement Division and Marion County Sheriff's Office are working to determine what caused the fire.