Horry County police say Katharine Joy Cooper, 52, hasn't been seen since Monday.
They say they believe Cooper left her home on Folly Road in the Socastee area around 9:00 p.m. without taking any personal belongings.
Family members and co-workers became concerned when they were unable to reach her.
She is described as white, 5'8" tall, weighing about 200 pounds. She has reddish brown hair and blue eyes. She is believed to be driving a gray 2006 Toyota Camry with a South Carolina tag of DLU 612.
Detectives are asking anyone with information about Ms. Cooper to call them at 843-915-5350 or 843-248-1520.