The Darlington County Sheriff's Office is searching for Nancy Elizabeth Morris Gainey, 29, of Hartsville.
She was last seen around noon Friday in the 2800 block of Patrick Highway Hartsville.
Gainey has a history of medical problems, according to deputies.
She was wearing blue jeans, white tank top and pink flip-flops.
Gainey was also carrying a black pocketbook with a Gamecock symbol on the side, according to deputies.
If you have any information, you're asked to call the Darlington County Sheriff's Office at (843) 398-4501.