Sheriff Wayne Byrd says the men were armed with weapons and left the store with an undisclosed amount of money.
Byrd says they got away in a small, tan van.
Jerrod Samuels is one of the suspects in the robbery, according to Sheriff Byrd.
Deputies are canvassing the area looking for any signs of the suspects.
If you have any information, you're asked to call the Darlington County Sheriff's Department at 843-398-4920.