Darlington County deputies are looking for Lewis Reep, 84 and his wife, Allene Reep, 79.
They left their home on Allen Road about 12:30 p.m. Thursday.
Mr. Reep suffers from Alzheimer's disease and Mrs. Reep has memory loss at times, according to Darlington County deputies.
They may be in a white 2000 four-door Toyota Camry, with South Carolina license tag HRD-682.
If you have any information about where they may be, you're asked to call the Darlington County Sheriff's Office at (843) 398-4920 or your local police.