The Darlington County Sheriff's Office is searching for Ronald Alford, 42.
Deputies said Alford was last seen at a home on Salley Street in Darlington last Friday getting ready for work.
Officers said he never made it to work and hasn't been seen or heard from since.
Deputies add he may be traveling in a 1999 green Tahoe with SC License tag HYI-314.
If you have any information into the disappearance of Ronald Alford, you're asked to call the Darlington County Sheriff's Office at (843) 398-4501.