Horry County Fire Rescue and Conway Fire crews are investigating an overnight mobile home fire in Conway.
The fire started around 2 a.m. Monday at 1806 New Road.
Two women and two men were injured and taken to a Conway hospital, according to Assistant Chief Scott Thompson with Horry County Fire Rescue.
Thompson said a 55-year-old man is critically injured from smoke inhalation.
The home is a total loss, according to Thompson.
Fire investigators are on the scene trying to determine the cause.