Midway Fire Rescue units are on scene of a commercial structure fire at Cohen's Drywall off Petigru Road in Pawleys Island.
Flames were shooting through the roof when crews arrived on scene.
The two owners of the warehouse discovered the fire around 9 a.m. Monday morning, according to Midway Fire Rescue Division Chief Todd Blomdahl.
There were three units from Midway Fire Rescue, one from Georgetown City fire as well as Murrells Inlet-Garden City units on scene.
The majority of the fire has been knocked down but units are staying on scene due to the threat of "combustible storage" in the warehouse, Blomdahl added.
No cause has been determined, but they know the fire originated in a corner of the warehouse.
Blomdahl said less than half the warehouse was destroyed.