Thu Tran, 43, of Dillon, is charged with Abuse to Inflict Great Bodily Injury on a Child, after hurting the 4-month-old she was babysitting, police said.
Florence police indicated Tran was babysitting the child at a home on Second Loop Road last week.
Someone from the home called 911 saying the baby was unresponsive.
Police added that the child underwent surgery for head trauma from shaken baby syndrome and that Tran was taking care of the infant when the injuries occurred.
Tran is out of jail on bond.