An 11-foot alligator, found in a yard on Helena Street in Georgetown, was shot and killed around 3 a.m. Thursday.
It was called in by residents in the area as a nuisance alligator.
Tommy and Robin Rogers have lived in the neighborhood for 23 years, and say they've never seen a gator that big.
"He was pretty upset because he was rising up and making that hissing noise like they do," said Tommy.
Dean Cain, with the Department of Natural Resources, said this time of year is when alligators start to relocate.
"It's actually quite normal and common for them to come out of a small say drainage pond in a residential area and move up on to the waters edge or even in somebody's yard. That's really fairly normal," said Cain.
The gator was probably injured and too large to relocate, Cain added.
"In many incidences the alligator may be injured and under that condition, alligators cannot be operated on or fixed. Also there's no rehabilitation facility in the state that alligators can be taken to."
As standard practice, Cain says most gators over 6-feet are killed because they are too hard to relocate.
It was taken to Florence to be processed for meat.
Yesterday, a 10-foot alligator was shot and killed in the surf at Folly Beach southeast of Charleston.
Angus McBride, with the Department of Natural Resources, says it's not unusual for alligators to get caught in tidal waters and end up in the ocean. McBride said alligators do not like salt water.
Alligator specialist Ray Covington with Nuisance Removal Wildlife Service shot the gator in the head and hauled it away.
Some people complained about shooting the alligator on the beach but Covington says the animal was sick and was too large to relocate.
He says it would have been too dangerous to try to remove the alligator and shoot it elsewhere.
The Associated Press contributed to this report.